SETBP1 in Myeloid Malignancies—Putting Breadcrumbs Together in Rare, Uncommon, and Common Pediatric Cases

نویسندگان

چکیده

In resource-constraint settings, genetic testing is rarely available for patients. We report the association of SETBP1, a major oncogene interest in myeloid malignancies, with juvenile myelomonocytic leukemia (JMML) and GATA 1 mutation. The modulating role SETBP1 Rat sarcoma virus (RAS)-driven especially JMML, unknown. vivo vitro studies point to aggressive leukemogenesis.[1] mutation not considered primary event.[2] RAS PTPN11, protein tyrosine phosphatase nonreceptor type 11 (PTPN11) confers both self-renewal oncogenic transformation. outcome confounding mutations like PTPN11 interlinked pathways Mitogen-activated kinase (MAPK) may be difficult predict.[3] [4] co-association JMML an independent poor prognostic factor[5] confounds effects those associated SETBP1. also has outcomes post-hematopoietic stem cell transplantation patients.[3]

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ژورنال

عنوان ژورنال: Indian Journal of Medical and Paediatric Oncology

سال: 2023

ISSN: ['0971-5851', '0975-2129']

DOI: https://doi.org/10.1055/s-0043-1769491